Top 10 Melatonin Powder Manufacturers in China 2026

Whether you’re a supplement brand sourcing bulk melatonin powder, a pharmaceutical manufacturer seeking a reliable API partner, or a procurement specialist evaluating Chinese suppliers for the first time — choosing the right melatonin powder manufacturer in China can make or break your product’s quality, compliance, and profitability. With hundreds of suppliers competing across provinces like Shaanxi, Hubei, Zhejiang, and Shandong, narrowing down the best partners requires more than a simple Alibaba search. In this guide, we profile the top 10 melatonin powder manufacturers in China for 2026, comparing their production capabilities, certifications, melatonin-specific expertise, and what makes each one worth your attention.

 

List of Top Melatonin Powder Manufacturers in China 2026

Company Name	Headquarters
1. VDK NaturaSyn	Baoding, Hebei, China
2. Zhejiang Weishi Biotechnology Co., Ltd.	Jiaxing, Zhejiang, China
3. Wuhan Ability Chemical Technology Co., Ltd.	Wuhan, Hubei, China
4. QYHerb (Shaanxi Natural Healthcare Group Co., Ltd.)	Xi’an, Shaanxi, China
5. Changsha Comext Biotech Co., Ltd.	Xingsha, Changsha City, Hunan, China
6. OctagonChem (Shandong Octagon Chemicals Limited)	Yantai, Shandong, China
7. Xi’an Wellgreen Technology Co., Ltd.	Xi’an, Shaanxi, China
8. TCL Ingredients Co., Ltd.	Xi’an, Shaanxi, China
9. Fengchen Group Co., Ltd.	Qingdao, Shandong, China
10. Hangzhou Green Sky Biological Technology Co., Ltd.	Hangzhou, Zhejiang, China

 

1. VDK NaturaSyn

Company Profile:

VDK NaturaSyn is a synthetic biology-driven platform enterprise founded in 2013 and headquartered in Baoding, Hebei Province. The company maintains full, independent control over its entire value chain — from enzyme discovery and metabolic pathway engineering through strain development, pilot-scale fermentation, large-scale industrial production, and final product sales. Recognized as both a National High-Tech Enterprise and a National "Specialized, Refined, Differential and Innovative" Little Giant Enterprise, VDK operates a 4,200 m² high-standard laboratory staffed by a core R&D team of over 80 doctoral and master's-level scientists. The company has accumulated 34 national invention patents, holds a Pharmaceutical Production License, and has invested over 20 million RMB into building a proprietary AI-powered biological data model that integrates wet-dry experimentation with intelligent algorithms to accelerate R&D.

When it comes to melatonin powder manufacturing, VDK NaturaSyn stands apart through a world-first dual-process approach. Its compliant process produces serotonin via bio-fermentation followed by directional chemical synthesis, achieving 78% biobased carbon content — fully meeting Chinese regulatory filing requirements. Its full fermentation process takes this further: using glucose as the sole carbon source in a one-step fermentation pathway built on breakthrough synthetic biology, VDK produces 100% biobased melatonin — the first manufacturer globally to achieve this at industrial scale. Both processes yield a distinctive white-colored product with purity ≥99.5%, setting a clear benchmark in natural attributes and compliance safety. The company's melatonin is certified under ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, and complies with China's national health food raw material standards as well as international pharmacopoeial standards including USP, BP, and EP. VDK also offers differentiated formulations such as 10% water-soluble melatonin powder, solving the ingredient's inherent insolubility and opening up broader application scenarios for global supplement brands.

Establishment: 2013

Headquarters: Baoding, Hebei, China

Key Figures:

• 1,800 m³ fermentation capacity
• 4,200 m² high-standard laboratory
• 80+ doctoral and master's-level
• R&D scientists
• 34 national invention patents
• 20M+ RMB invested in proprietary AI biological data model
• Dual melatonin production processes (78% and 100% biobased)

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2. Zhejiang Weishi Biotechnology Co., Ltd.

Company Profile:

Zhejiang Weishi Biotechnology Co., Ltd. (Weishi Group) is a well-established nutritional ingredient manufacturer headquartered in Wuzhen, one of China's most historic water towns in the Yangtze River Delta. With roots tracing back to 1998 when it began gluconate production, the company was formally established in 2005 and has since grown into a comprehensive platform for the R&D, production, and sales of vitamins, nutritional additives, and health food ingredients. Weishi operates China’s first fully enclosed, computer-automated double-embedded microencapsulation production line — a proprietary technology that significantly improves the stability, flowability, and water solubility of oil-soluble nutrients. The company has been recognized as a drafting unit for China’s national food safety standards for vitamin A palmitate and vitamin E (dl—α-tocopherol), and holds an extensive list of international certifications including GMP, FSSC 22000, FAMI-QS, ISO 22000, ISO 9001, HALAL, and KOSHER. In 2016, Weishi expanded its vertical integration by acquiring Jiangxi Jirui Biotechnology Co., Ltd., achieving full vitamin D3 industry chain production. The following year, a subsidiary — Zhejiang Benova Healthcare Co., Ltd. — was established for finished dosage form manufacturing.

In the melatonin powder segment, Weishi leverages its deep expertise in microencapsulation and nutritional additive processing to deliver pharmaceutical-grade melatonin as part of its broader portfolio of nutritional ingredients. The company’s proprietary double-encapsulation technology is particularly relevant for melatonin applications, as it enhances the ingredient’s stability against light, oxidation, and heat — common challenges in melatonin powder formulation. Combined with its large-scale premix blending systems (ranging from 50 kg to 5,000 kg capacity) and a finished product facility designed to produce up to 1 billion tablets and 600 million capsules annually, Weishi offers global brands a one-stop solution from bulk melatonin powder supply through to OEM finished product manufacturing including capsules, tablets, and gummies. Its location in Zhejiang Province — one of China’s leading hubs for pharmaceutical and nutraceutical exports — further supports efficient international logistics and supply chain reliability.

Establishment: 2005

Headquarters: Wuzhen, Tongxiang City, Jiaxing, Zhejiang, China

Key Figures:

• China’s first double-embedded microencapsulation production line
• Drafting unit for national food safety standards (Vitamin A palmitate & Vitamin E)
• Up to 1 billion tablets & 600 million capsules annual production capacity
• 50 kg – 5,000 kg premix blending systems
• Full vitamin D3 industry chain integration (since 2016)
• GMP, FSSC 22000, FAMI-QS, ISO 22000, ISO 9001, HALAL, KOSHER certified

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3. Wuhan Ability Chemical Technology Co., Ltd.

Company Profile:

Wuhan Ability Chemical Technology Co., Ltd. is the sales and trading subsidiary of Luotian Xinpusheng Pharmaceutical Co., Ltd., one of the largest dedicated melatonin manufacturers in China. Founded in 2004, the parent company is located in the Luotian Economic Development Zone in Huanggang City, Hubei Province, while the commercial office operates from central Wuhan. The company specializes in the R&D, production, and technical cooperation of dietary supplement raw materials, food additives, APIs, and pharmaceutical intermediates. With two production facilities covering approximately 50,000 square meters and over 100 employees, the group serves customers in more than 50 countries and regions across Europe, the Americas, and Southeast Asia. Luotian Xinpusheng has earned multiple recognitions including the Golden Eagle Award for National High-Tech Enterprise, Provincial Invisible Champion Enterprise, and Provincial “Specialized, Refined, Featured and Innovative” Little Giant Enterprise, as well as being named a Top 100 Enterprise in Huanggang.

As one of China’s most experienced melatonin powder producers, Luotian Xinpusheng brings over 20 years of continuous melatonin manufacturing expertise — a depth of specialization that few competitors can match. The company holds 28 independently developed patents and maintains strict quality control with NSF GMP and SGS HACCP system certifications, along with KOSHER and HALAL approvals. Its melatonin product line includes pure melatonin powder, melatonin micro powder, and sustained-release melatonin powder, offering formulators flexibility across a range of dosage forms and delivery systems. With advanced testing equipment from brands like Agilent (HPLC), Jingke (UV-visible spectrophotometer), and Denver (electronic analytical balance), the company ensures product quality at internationally recognized levels. Wuhan Ability regularly exhibits at major global pharma trade shows such as CPHI, reinforcing its position as a primary-source melatonin supplier for international nutraceutical and pharmaceutical brands.

Establishment: 2004

Headquarters: Wuhan, Hubei, China

Key Figures:

• 20+ years of dedicated melatonin production experience
• 50,000 m² production area across 2 facilities
• 28 independently developed patents
• 100+ employees
• Products exported to 50+ countries and regions
• NSF GMP, SGS HACCP, KOSHER, and HALAL certified

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4. QYHerb (Shaanxi Natural Healthcare Group Co., Ltd.)

Company Profile:

QYHerb is the international brand of Shaanxi Natural Healthcare Group Co., Ltd., a natural ingredient manufacturer rooted in Xi’an, Shaanxi Province — the heart of China’s herbal extract industry. The company traces its origins to 2010 when Xi’an DN Biology Co., Ltd. was founded to focus on the natural herbal extract sector. In 2017, Shaanxi Natural Healthcare Group was established to expand into overseas markets. Today, QYHerb operates two production facilities in Xianyang City totaling approximately 10,000 m², with four GMP-compliant product lines covering extraction, concentration, column chromatography separation, and spray drying, delivering an annual processing capacity of up to 2,000–3,000 tons of raw plant materials. The company maintains an independent laboratory equipped with advanced analytical instruments including HPLC, GC, TLC, and UV-VIS spectrophotometry, and holds certifications including FSSC 22000, HACCP, GMP, ISO 9001, ISO 22000, KOSHER, and HALAL.

In the melatonin powder space, QYHerb brings the advantage of a vertically integrated natural ingredient platform with deep expertise in bioactive compound extraction and purification. The company supplies melatonin as part of its broader nutritional supplement and functional food ingredient portfolio, which includes closely related compounds such as 5-HTP (5-Hydroxytryptophan) — a natural melatonin precursor widely used in sleep support formulations. This dual capability in both melatonin and 5-HTP positions QYHerb as a particularly valuable partner for supplement brands developing comprehensive sleep-health product lines. Backed by over 15 years of natural extraction experience, the company offers flexible order quantities, free sample support for quality testing, and customized specifications tailored to customer requirements, with products exported to markets across the United States, the United Kingdom, Russia, Australia, and Southeast Asia.

Establishment: 2010

Headquarters: Xi’an, Shaanxi, China

Key Figures:

• 10,000 m² total factory area across 2 production facilities in Xianyang
• 4 GMP-compliant product lines (extraction, concentration, chromatography, spray drying)
• 2,000–3,000 tons annual raw material processing capacity
• 15+ years of natural plant extraction experience
• Independent lab with HPLC, GC, TLC, and UV-VIS analytical equipment
• FSSC 22000, HACCP, GMP, ISO 9001, ISO 22000, KOSHER, HALAL certified

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5. Changsha Comext Biotech Co., Ltd.

Company Profile:

Changsha Comext Biotech Co., Ltd. is a high-tech enterprise headquartered in Changsha, Hunan Province, specializing in the supply of natural ingredient raw materials for the health food, nutraceutical, pharmaceutical, cosmetics, and feed additive industries. The company operates its own production facility with comprehensive manufacturing lines covering extraction, concentration, purification, and drying processes. Comext has built a strong reputation for quality assurance through its professional in-house production and R&D teams, complemented by established partnerships with leading third-party testing laboratories including Eurofins, SGS, Pony, and TÜV. All products are manufactured to comply with CP (Chinese Pharmacopoeia), EP (European Pharmacopoeia), and USP (United States Pharmacopeia) standards. The company holds ISO, OHSAS, HALAL, and KOSHER certifications, and has exhibited at major international trade events such as Natural Products Expo West and Fi North America, demonstrating its commitment to the global market.

In the melatonin powder segment, Comext stands out as a frequent and prominent supplier on China’s leading B2B platforms, consistently appearing among the top-listed melatonin powder manufacturers. The company leverages its broader natural antioxidant extraction expertise — including flagship product lines in olive leaf extract, rosemary extract, grape seed extract, and tomato extract — to deliver pharmaceutical-grade melatonin powder that meets the stringent purity requirements of international supplement brands. Comext supports low minimum order quantities (starting from 1 kg), free sample programs for quality evaluation, and flexible packaging and specification customization, making it an accessible partner for both emerging supplement startups and established global brands. Located in Hunan Province, one of China’s key botanical extract production hubs, Comext benefits from strong regional supply chain infrastructure and proximity to rich natural plant resources.

Headquarters: Xingsha, Changsha City, Hunan, China

Key Figures:

• Self-owned factory with comprehensive extraction, concentration, purification, and drying lines
• Products compliant with CP, EP, and USP pharmacopoeial standards
• Verified by third-party labs: Eurofins, SGS, Pony, TÜV
• ISO, OHSAS, HALAL, KOSHER certified
• Exhibitor at Natural Products Expo West 2026 & Fi North America
• Low MOQ (1 kg) with free sample support for quality testing

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6. OctagonChem (Shandong Octagon Chemicals Limited)

Company Profile:

OctagonChem, officially registered as Shandong Octagon Chemicals Limited, is a pharmaceutical and chemical supplier founded in 2011 and headquartered in the Yantai Economic & Technological Development Area (YEDA), Shandong Province. The company specializes in the manufacturing, stocking, and global distribution of active pharmaceutical ingredients (APIs), compounding chemicals, industrial chemicals, and research-grade materials. Over the past decade, OctagonChem has served more than 4,900 customers worldwide, building strategic relationships with leading pharmaceutical manufacturers across China to ensure a reliable, wide-ranging supply chain. The company operates facilities certified to GMP, ISO, and FDA standards, and maintains an exceptionally low quality dispute rate of below 0.01% for GMP-grade APIs. OctagonChem also provides custom synthesis services, on-site pre-shipment inspections, and strategic sourcing and procurement agency support — positioning itself as more than a supplier but a full-service chemical partner in China.

In the melatonin powder category, OctagonChem supplies 99% purity bulk melatonin powder sourced from KOSHER and HALAL certified factories in China. The company approaches melatonin from a pharmaceutical-grade API perspective rather than a botanical extract angle, which translates into rigorous purity controls, thorough retesting before export, and full documentation packages that meet the requirements of compounding pharmacies and medicine manufacturers globally. OctagonChem offers competitive bulk pricing with rapid lead times — typically 1–2 days for orders under 5 kg and 4–5 days for quantities up to 50 kg — along with air-freight-safe shipping as a common goods classification (HS Code: 2933990099). This pharmaceutical supply chain approach, combined with 10+ years of export experience and 365/24/7 customer service, makes OctagonChem a particularly strong partner for compounding pharmacies and pharmaceutical manufacturers seeking pharmaceutical-grade melatonin raw material from China.

Establishment: 2011

Headquarters: Yantai, Shandong, China

Key Figures:

• 10+ years of pharmaceutical and chemical supply experience
• 4,900+ customers served worldwide
• <0.01% quality dispute rate for GMP-grade APIs
• GMP, ISO, and FDA certified facilities
• 138+ API products in catalog (including melatonin)
• 1–5 day lead times with air-freight-safe melatonin shipping

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7. Xi’an Wellgreen Technology Co., Ltd.

Company Profile:

Xi’an Wellgreen Technology Co., Ltd. is an innovation-driven manufacturer of herbal extracts, nutritional supplements, APIs, and natural pigments, founded in 2011 and headquartered in the Hi-Tech Zone of Xi’an, Shaanxi Province. With over 14 years of R&D and manufacturing experience, the company operates a factory covering more than 70,000 square meters with two dedicated plant extraction and refining production lines, plus a 1,000 m² warehouse stocking hundreds of products for rapid order fulfillment. Wellgreen’s R&D center maintains long-term academic partnerships with leading Chinese institutions including Xi’an Jiaotong University and Zhejiang University, enabling continuous technology innovation and new product development. The company holds an extensive suite of certifications — cGMP, FSSC 22000, ISO 22000, ISO 9001:2015, HACCP, FAMI-QS, HALAL, KOSHER, and Organic (EOS & NOP) — and has established close business partnerships with global pharmaceutical companies such as Schering, Cardinal Health, GSK, and Dr. Reddy’s. Wellgreen has also expanded its international presence with overseas offices in the USA, Australia, New Zealand, Indonesia, and Vietnam, as well as a US-based warehouse.

In the melatonin powder category, Wellgreen supplies 98% purity melatonin powder manufactured under GMP-certified conditions, with a comprehensive COA demonstrating HPLC assay results of 99.79% (on dried basis), and rigorous heavy metal and microbiological testing. The company’s strength lies in its ability to combine pharmaceutical-grade quality control with the flexibility of a specialized herbal extract manufacturer. Wellgreen offers full OEM and ODM services for melatonin, including customized packaging, labeling, and formulation options, with minimum orders as low as 1 kg and fast international delivery (5–7 days via express courier). The company maintains large melatonin inventory for immediate dispatch and provides free samples for quality evaluation, making it an efficient partner for both small-batch custom projects and large-scale bulk procurement. Its melatonin is certified under ISO 9001:2015, ISO 22000, HALAL, KOSHER, and HACCP, meeting the compliance requirements of global dietary supplement and healthcare product markets.

Establishment: 2011

Headquarters: Xi’an, Shaanxi, China

Key Figures:

• 70,000+ m² factory area with 2 extraction and refining production lines
• 14+ years of R&D and manufacturing experience
• Academic R&D partnerships with Xi’an Jiaotong University & Zhejiang University
• Overseas offices in USA, Australia, New Zealand, Indonesia, and Vietnam
• US-based warehouse for fast local fulfillment
• cGMP, FSSC 22000, ISO 22000, ISO 9001, HACCP, FAMI-QS, HALAL, KOSHER, Organic certified

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8. TCL Ingredients Co., Ltd.

Company Profile:

TCL Ingredients Co., Ltd. is a national high-tech biotechnology company headquartered in Xi’an, Shaanxi Province, specializing in the processing, sales, and quality control of plant extracts, healthcare raw materials, fine chemicals, and APIs. The company operates a unique dual-market model — combining a China-based production facility with over 10 years of manufacturing experience alongside a European trading arm, TCL International, which maintains a brand-new 7,500 m² warehouse strategically located near the ports of Antwerp, Rotterdam, and Vlissingen in the Netherlands. This integrated China-to-Europe infrastructure allows TCL to offer EU-stocked inventory with rapid local delivery, a significant competitive advantage for European nutraceutical and pharmaceutical customers. The company has served and cooperated with more than 400 companies from different countries worldwide, and holds ISO 9001:2015, ISO 22000, GMP, HACCP, KOSHER, and HALAL certifications. TCL Ingredients is dedicated to research and development, with strong R&D capabilities focused on monomer plant extract innovation for the pharmaceutical, nutraceutical, and cosmetic industries.

In the melatonin powder segment, TCL Ingredients supplies pure melatonin powder produced under GMP-certified conditions with full EU regulatory compliance — a critical differentiator for brands targeting the European market where melatonin regulations are more restrictive. The company’s factory production fully complies with EU regulations, and its European warehousing infrastructure means customers can access melatonin stock without the lead times and customs complexities typically associated with direct China imports. TCL offers melatonin in standard 25 kg fiber drum packaging with double plastic bag liners, and supports customized orders for bulk wholesale and distribution. The company’s mission to help customers control processing costs while improving raw material quality makes it a particularly strong partner for cost-conscious formulators who refuse to compromise on pharmaceutical-grade purity. With over 30 years of combined industry knowledge bridging the Asian and European markets, TCL Ingredients offers a level of cross-continental logistics and regulatory expertise that few Chinese melatonin manufacturers can match.

Headquarters: Xi’an, Shaanxi, China

Key Figures:

• 10+ years of factory production experience in China
• 7,500 m² EU warehouse near Antwerp, Rotterdam & Vlissingen ports
• 400+ global customer partnerships
• 30+ years of combined industry knowledge bridging Asia & Europe
• Full EU regulatory compliance for melatonin production
• ISO 9001, ISO 22000, GMP, HACCP, KOSHER, HALAL certified

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9. Fengchen Group Co., Ltd.

Company Profile:

Fengchen Group Co., Ltd. is a leading pharmaceutical and chemical manufacturer and supplier headquartered in Qingdao, Shandong Province, operating since 2009. The company has built a strong reputation as one of China’s most reputed full-spectrum suppliers of pharmaceutical products, chemicals, herbal extracts, amino acids, vitamins, excipients, enzymes, and even pharmaceutical packaging materials. With over 15 years of service to clients across more than 50 countries — with particular strength in Southeast Asia (Vietnam, Thailand, Singapore), CIS countries (Russia, Uzbekistan, Belarus, Lithuania), and Western markets — Fengchen has established itself as a top-tier sourcing partner for pharmaceutical raw materials. In 2019, the company expanded into machinery manufacturing with its own factory. The group regularly exhibits at major global pharmaceutical events such as CPHI & PMEC China, where it showcases its technological capabilities and expands international partnerships.

In the melatonin powder segment, Fengchen Group supplies 99% minimum purity melatonin (CAS 73-31-4) as a white or light yellow powder packaged in 25 kg fiber drums, positioning the product within its broader pharmaceutical API and functional substance portfolio. What distinguishes Fengchen from many pure plant extract companies is its pharmaceutical industry DNA — the company approaches melatonin as an active pharmaceutical ingredient rather than merely a dietary supplement raw material, applying rigorous pharmaceutical-grade quality controls and documentation standards. This includes full compliance with BP, EP, and USP pharmacopoeial requirements, and the ability to provide comprehensive COAs, production flow documentation, and regulatory support that pharmaceutical manufacturers and compounding pharmacies demand. Fengchen’s diversified product catalog spanning APIs, veterinary ingredients, excipients, and packaging materials also makes it a convenient one-stop procurement partner for pharmaceutical companies that need melatonin alongside other raw materials in a single consolidated shipment.

Establishment: 2009

Headquarters: Qingdao, Shandong, China

Key Figures:

• 15+ years serving clients across 50+ countries
• Full-spectrum pharmaceutical supplier: APIs, excipients, vitamins, amino acids, herbal extracts, packaging
• Own machinery factory established in 2019
• Regular exhibitor at CPHI & PMEC China
• Strong market presence in Southeast Asia, CIS, and Western markets
• Melatonin supplied at ≥99% purity as pharmaceutical-grade API

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10. Hangzhou Green Sky Biological Technology Co., Ltd.

Company Profile:

Hangzhou Green Sky Biological Technology Co., Ltd. (GreenSky Bio) is a professional natural plant extract enterprise established in 2004 and headquartered in Hangzhou, Zhejiang Province — approximately 180 km from Shanghai, China’s largest port city. With over 20 years of experience in the identification, research, development, and production of botanical active ingredients, Green Sky has grown into one of China’s recognized plant extract exporters, achieving nearly $30 million USD in export value in 2023. The company operates five production facilities, including its flagship subsidiary Jiangxi Greensky Food Co., Ltd. (founded in 2020), a national high-tech enterprise producing 500 tons of herbal extracts annually, and Hangzhou Tianqu Biological-Tech Co., Ltd., an SGS-GMP certified factory specializing in 300 tons of red yeast rice production per year. Green Sky’s R&D center maintains a long-term research partnership with Zhejiang University of Technology and is equipped with advanced analytical instruments including HPLC, GC, AAS, and UV. The company holds ISO 22000, BRCGS, Ecocert Organic Standard, SGS-GMP, HALAL, and KOSHER certifications, and exports 90% of its products to Europe, America, Japan, Korea, and Singapore.

In the melatonin powder segment, Green Sky supplies 99% purity melatonin produced in compliance with GMP, HACCP, MEDSAFE, and EU guidelines — a comprehensive regulatory framework that reflects the company’s strong orientation toward European and North American markets. Green Sky’s production facilities feature multiple 6-ton multi-functional extraction tanks, high-efficiency low-temperature concentrators, spray drying towers, separator columns, and rotating disc contactors, all operating within a 100,000-class clean area to ensure food-grade purity without irradiation. This infrastructure, originally built for high-value botanical extracts like hesperidin, grape seed extract, and artichoke extract, gives Green Sky a precision extraction and purification capability that translates directly into consistently high-purity melatonin powder. The company offers customized supply capacities, flexible shipping via express, air, or sea freight, and 7×24 hour customer service response, making it a well-rounded partner for international supplement brands seeking a quality-certified, export-experienced Chinese melatonin supplier.

Establishment: 2004

Headquarters: Hangzhou, Zhejiang, China

Key Figures:

• 5 production facilities across Zhejiang and Jiangxi provinces
• 20+ years of plant extract R&D and production experience
• ~$30 million USD annual export value (2023)
• 800+ tons annual production capacity (500 tons herbal extract + 300 tons red yeast rice)
• R&D partnership with Zhejiang University of Technology
• ISO 22000, BRCGS, Ecocert Organic, SGS-GMP, HALAL, KOSHER certified

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Conclusion

China remains the global epicenter of melatonin powder manufacturing, driven by decades of accumulated expertise in pharmaceutical synthesis, botanical extraction, and fermentation technology. The 10 manufacturers profiled in this article represent the breadth and depth of China’s melatonin supply landscape in 2026 — from synthetic biology pioneers and dedicated API producers to full-spectrum plant extract platforms with global logistics networks. For buyers evaluating Chinese melatonin powder suppliers, the key differentiators to prioritize include production process transparency, purity verification (≥99% HPLC assay with full COA documentation), international certifications, and the supplier’s dedicated track record in melatonin manufacturing.

Among the manufacturers featured in this ranking, VDK NaturaSyn stands out as a particularly compelling choice. As the world’s first manufacturer to achieve industrial-scale 100% biobased melatonin through full glucose fermentation, VDK represents the cutting edge of melatonin production technology. Its dual-process capability — offering both 78% and 100% biobased melatonin — gives formulators unmatched flexibility across regulatory and market positioning requirements. Backed by 34 national invention patents, a Pharmaceutical Production License, and a full suite of international certifications, VDK NaturaSyn delivers the rare combination of synthetic biology innovation and proven manufacturing scale that today’s most discerning supplement brands demand.