Top 5 5-Hydroxytryptophan Manufacturers in China 2026

List of Top 5-HTP Manufacturers & Suppliers in China 2026

The following list represents the industry benchmark for quality control, production capacity, and R&D innovation in 5-HTP manufacturing.

1. Hunan Sunfull Bio-Tech Co., Ltd.

Company Profile:

Founded in 2008 and headquartered in Changsha, Hunan Province, Hunan Sunfull Bio-Tech Co., Ltd. is one of China's leading botanical extract manufacturers, specializing in high-value green tea and plant extracts for dietary supplements, beverages, cosmetics, and pharmaceuticals. The company is internationally recognized as a top producer of EGCG, L-theanine, and Theaflavins, with an expanding portfolio of APIs including Resveratrol, Magnolol, and Polydatin. Sunfull holds ISO9001, ISO22000, Kosher, HALAL, and HACCP certifications, exporting to North America, Europe, Southeast Asia, and the Middle East.

In the 5-Hydroxytryptophan category, Sunfull manufactures Griffonia simplicifolia seed extract sourced 100% naturally from Africa, with standardized specifications of 95%, 98%, and 99% purity verified by HPLC. Its multi-certification compliance supports export to regulated nutraceutical and pharmaceutical markets, while its independent R&D center and HPLC/UV/GC testing infrastructure ensure batch-to-batch consistency. These advantages make Sunfull a dependable Griffonia-based 5-HTP supplier for global supplement brands seeking traceability and regulatory readiness.

Establishment: 2008

Headquarters: Changsha, Hunan Province, China

Key Figures:

• The company operates 2 dedicated production lines at its Changsha manufacturing facility.
• Annual output value ranges between US$5 million and US$10 million, with peak reported sales surpassing US$15 million in 2019.
• Approximately 71%–90% of total production is exported to overseas markets.
• The R&D team consists of 11–50 specialized technical personnel.
• The total workforce ranges from 51 to 200 employees.
• The company offers OEM and design services with flexible international trade terms including FOB, CFR, CIF, EXW, CIP, and FCA.
• Shipments are dispatched primarily through the ports of Changsha, Shanghai, and Guangzhou.

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2. Shaanxi Jiahe Phytochem Co., Ltd. (JIAHERB)

Company Profile:

Founded in 2000 and headquartered in Xixian New District, Shaanxi Province, Shaanxi Jiahe Phytochem Co., Ltd. — globally branded as JIAHERB — is one of China's most prominent botanical extract manufacturers. The company is dedicated to the identification, development, and production of natural plant extracts and derivatives serving the pharmaceutical, nutraceutical, cosmetic, and food & beverage industries. JIAHERB holds cGMP, ISO 9001, ISO 14001, Kosher, Halal, and HACCP certifications, and operates a CNAS-certified R&D center alongside multiple production facilities. With over 500 botanical ingredients in its catalog and a global supply network, JIAHERB has established itself as a trusted partner for international supplement and pharmaceutical brands.

JIAHERB lists 5-HTP among its core chemical ingredients, alongside Huperzine-A, Shikimic Acid, and Salicin — reflecting its specialized expertise in high-purity active compound manufacturing beyond standard botanical extracts. Its Griffonia simplicifolia–derived 5-Hydroxytryptophan benefits from JIAHERB's GAP-controlled herb planting bases, which ensure raw material continuity and traceability. The company's advanced analytical infrastructure — including HPLC, GC, UV, HPTLC, GC/LC-MS-MS, and ICP-MS — supports rigorous purity verification, heavy metal screening, pesticide residue testing, and microbiological control. Combined with cGMP and Kosher/Halal compliance, these capabilities make JIAHERB a reliable 5-HTP supplier for export-oriented buyers in regulated markets.

Established: 2000

Headquarters: Xi'an, Shaanxi, China

Key Figures:

• The company operates 4 manufacturing factories across its production network.
• The total workforce exceeds 1,500 employees across all facilities.
• JIAHERB holds more than 50 authorized patents and over 100 patents in total registered under the group.
• The company produces over 500 botanical extracts and ingredients in its commercial catalog.
• JIAHERB maintains 2 independent laboratories for R&D and quality control.
• Products are exported to North America, South America, Europe, Russia, East Asia, Southeast Asia, Australia, and New Zealand.
• The U.S. subsidiary JIAHERB, INC., established in 2008, is among the largest NSF-GMP registered herbal extract manufacturers in North America.

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3. Hunan Nutramax Inc.

Company Profile:

Founded in 2008 and headquartered in the High-Tech Zone of Changsha, Hunan Province, Hunan Nutramax Inc. is a publicly listed botanical extract manufacturer (New Third Board, stock code 831319) specializing in natural sweeteners and plant extracts. The company operates a fully integrated industry chain spanning plant cultivation, extraction manufacturing, and health-nutrition supply, supported by its own organic planting bases for Monk Fruit, Sweet Tea, Cyclocarya paliurus, and Polygonum cuspidatum. Nutramax holds BRC, USDA & EU Organic, cGMP, Non-GMO, ISO22000, ISO9001, Halal, Kosher, and SC certifications. As Chairman unit of the Hunan Botanical Extract Association and a drafter of China's Plant Extract Industry Standards, the company exports globally through its Los Angeles–based U.S. sales subsidiary.

For 5-Hydroxytryptophan, Hunan Nutramax produces Griffonia simplicifolia seed extract sourced from West African origins (Ghana, Ivory Coast, Togo) at 98% and 99% HPLC-verified purity, using alcohol-based extraction. Its strengths include a strong R&D team supported by collaboration with Hunan Agricultural University and the Hunan Engineering & Technology Research Center for Natural Products. Combined with cGMP-certified manufacturing, multi-market regulatory compliance, and direct U.S. distribution, Nutramax offers reliable, traceable 5-HTP supply for global supplement and pharmaceutical brands.

Established: 2008

Headquarters: Changsha, Hunan, China

Key Figures:

• The company operates two cGMP-certified plant extract manufacturing facilities, including the Changsha High-Tech Zone factory and Hunan Sweetmax Inc.
• Annual raw material processing capacity reaches 30,000 tons, with finished plant extract output of up to 800 tons per year.
• Total botanical extract production capacity exceeds 1,000 tons annually across all product lines.
• The R&D team includes more than 42 scientists, many holding PhD or Master's degrees in phyto-chemistry, pharmacology, and traditional Chinese medicine.
• The company has developed 240 standardized extracts and is capable of manufacturing more than 900 types of botanical extracts.
• Self-owned planting bases cover over 50,000 mu (approximately 3,333 hectares), including 40,000 mu of Monk Fruit and 5,000 mu of Sweet Tea cultivation.
• Products are exported to North America, Europe, Southeast Asia, and other major global markets through its wholly-owned subsidiary in Los Angeles, USA.

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4. Acetar Bio-Tech

Company Profile:

Founded in 2004 and headquartered in Xi'an, Shaanxi Province, Xi'an Acetar Bio-Tech Inc. is a publicly listed national high-tech enterprise (NEEQ stock code 831942) specializing in plant extracts, organic plant-based proteins, health food raw materials, and feed additives. Acetar is recognized as the first listed plant extract company in Shaanxi Province and the third in China within the industry. The company's core product portfolio includes Ginkgo biloba extract, St. John's Wort extract, Scutellaria baicalensis extract, and pumpkin seed protein, exported to Europe, the Americas, Southeast Asia, and Japan. With cGMP, ISO22000, FSSC22000, HACCP, Organic, Kosher, Halal, and Non-GMO certifications, Acetar maintains a strong presence in regulated international markets and operates a U.S. office in California (since 2016) for faster regional distribution.

5-HTP is included among Acetar's core herbal extract offerings, supported by its comprehensive cGMP-certified manufacturing infrastructure and rigorous in-house testing standards. The company's strengths in 5-Hydroxytryptophan supply include integrated extraction capabilities at its two GMP-compliant plant extraction lines, multi-market regulatory compliance (Kosher, Halal, Non-GMO), and a U.S.-based local inventory system that enables faster, more reliable delivery to North American buyers. These factors make Acetar a competitive 5-HTP source for dietary supplement, pharmaceutical, and food formulation buyers worldwide.

Established: 2004

Headquarters: Xi'an, Shaanxi, China

Key Figures:

• The company operates two GMP-standard plant extraction production lines located in Zhouzhi County and Feng Xian County.
• Annual raw material processing capacity reaches 5,000 tons of natural plants.
• The manufacturing facility is designed to produce up to 1,500 metric tons of Pumpkin Seed Protein Powder per year.
• Overseas sales account for approximately 70% of total revenue, with primary export markets in North and South America.
• The company markets more than 100 commercialized products across plant extract and protein categories.
• Acetar employs more than 100 staff, with college-educated and technical personnel accounting for approximately 70% of the workforce.
• The company is publicly listed on China's NEEQ market under stock code 831942 and operates a U.S. office in California established in 2016.

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5. VDK NaturaSyn

Company Profile:

Operating since 2013 and headquartered in Baoding, Hebei Province, VDK NaturaSyn Co., Ltd. is a synthetic biology platform company specializing in the biosynthesized production of natural ingredients for dietary supplements, natural pigments, and flavors & fragrances. VDK has built a fully integrated, self-controlled production system covering enzyme discovery and optimization, metabolic pathway engineering, in-house strain development, pilot-scale fermentation, extraction and purification, and large-scale industrial manufacturing. Leveraging its proprietary microbial cell factory technology, the company enables sustainable, large-scale biological production of natural compounds including 5-HTP, Resveratrol, Astaxanthin, β-Carotene, and Melatonin. Committed to green and sustainable development, VDK applies biotechnology to deliver high-purity natural ingredients while reducing reliance on traditional botanical extraction.

In the 5-Hydroxytryptophan category, VDK has achieved a major technological breakthrough through a decade of R&D, employing a one-step glucose fermentation process that enables high-concentration large-scale production. Through directed branch metabolism optimization, total impurities before the main peak are controlled at <0.01%, meeting USP standards. VDK® Natural 5-HTP is verified Peak X–free, supported by a Naturalness Test Report confirming 100% biobased carbon, with assay purity ≥99.0%. The company offers multi-specification supply — including granular, water-soluble, and liposomal forms — to support personalized formulation needs across nutraceutical and pharmaceutical applications.

Established: 2013

Headquarters: Baoding, Hebei, China

Key Figures:

• The company operates a large-scale fermentation production system with a total capacity of 1,500 cubic meters.
• VDK maintains a 4,200-square-meter high-standard laboratory equipped with cutting-edge analytical and process equipment.
• The R&D team consists of more than 44 doctoral and master's degree holders specializing in synthetic biology and fermentation engineering.
• The company has cumulatively obtained 37 authorized national invention patents.
• VDK® Natural 5-HTP achieves an assay purity of ≥99.0%, with total impurities controlled at ≤0.3% and Peak X verified absent.
• The 5-HTP product line is supplied in multiple forms including high-purity gradient powders, granular, water-soluble, and liposomal specifications, with packaging options of 1 kg, 5 kg, 10 kg, and 25 kg drums.
• All production-related facilities are independently invested and constructed by the company, ensuring full supply-chain control from strain development through finished product.

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